Here's a step-by-step guide to finding and installing the software on a compatible Mac.
If you are running a modern macOS (Big Sur, Monterey, Ventura, Sonoma, or Sequoia), you cannot use Total Integration natively. You must use the Virus TI as a traditional hardware synth via standard MIDI and Audio cables, or look into third-party emulation tools like Mystery Islands Music plugins or the Aura Plugins virus editor. How to Install 5.1.7.00 on Supported Intel Macs virus ti installer 5.1.7.00 for macos